Expert FDA Analysis

FDA Insights — Regulatory News,
Guidance & Expert Analysis

Practical guidance on FDA compliance, enforcement trends, and regulatory strategy — written by an RAC-certified consultant who works in the trenches every day.

Staying Ahead of FDA Regulatory Changes

The FDA regulatory landscape never stands still. New guidance documents, shifting enforcement priorities, evolving inspection protocols, and changing submission requirements create a constant challenge for companies that manufacture, distribute, or import FDA-regulated products. Whether you operate in pharmaceuticals, medical devices, food manufacturing, dietary supplements, or biologics — staying current on FDA developments is not optional. It is a business requirement.

This blog is built for regulatory affairs professionals, quality managers, compliance officers, and business leaders who need practical, actionable FDA intelligence. Every article is written or reviewed by Jared Clark, an RAC-certified FDA consultant with credentials spanning pharmaceutical GMP (CPGP), food safety auditing (CQA), quality management (CMQ-OE), and project management (PMP) — plus the legal perspective that comes with a JD.

You will find in-depth analysis of FDA warning letter trends, step-by-step inspection preparation guides, regulatory pathway comparisons for device and drug submissions, compliance checklists for foreign manufacturers, and strategic frameworks for responding to FDA enforcement actions. Each post connects regulatory requirements to real-world execution — because understanding what the FDA requires is only useful when you know how to implement it.

We cover all five major FDA centers: CDER (drugs), CDRH (medical devices), CFSAN (food and dietary supplements), CBER (biologics), and CVM (veterinary products). Whether your immediate concern is an upcoming FDA inspection, a pending 510(k) submission, a warning letter response deadline, or simply building a more robust compliance program — this blog provides the regulatory insight you need to make informed decisions.

New articles are published regularly. Subscribe below to receive FDA regulatory updates directly in your inbox — no spam, just expert analysis that helps you stay compliant and competitive.

General Aug 19, 2026

What FDA's Expanded Access Approval Means for Sponsors and Quality Teams

FDA cleared expanded access for daraxonrasib. Here's what the approval means for CGMP, quality systems, and audit readiness at sponsor and CDMO sites.

JC
Jared Clark
· 11 min read
Compliance Aug 12, 2026

Structure/Function Claims: Where Supplements Become Drugs

Learn how supplement claims cross into drug territory under FDA rules, why testimonials are the biggest risk, and how to build a claims review system that holds up.

JC
Jared Clark
· 12 min read
Compliance Aug 05, 2026

FDA Moves to Bar GLP-1 Compounding from Bulk Substances

FDA proposes excluding semaglutide, tirzepatide, and liraglutide from the 503B bulks list. Here's what it means for outsourcing facilities and clinics.

JC
Jared Clark
· 10 min read
Regulatory Affairs Jul 29, 2026

FDA Approves First Non-Antipsychotic Dementia Agitation Drug

FDA cleared Auvelity for dementia-related agitation without an antipsychotic boxed warning. Here's what sponsors and providers need to do next.

JC
Jared Clark
· 11 min read
Regulatory News & Analysis May 01, 2026

FDA's Animal Testing Alternatives: Year 1 Progress

FDA hit its Year 1 milestones on reducing animal testing in drug development. Here's what the progress means for your regulatory strategy. Expert analysis inside.

JC
Jared Clark
· 9 min read
Compliance Apr 17, 2026

Medicare Advantage 2027 Final Rule: What Plans Must Do Now

CMS's CY2027 Medicare Advantage & Part D final rule is live. Learn what changed in Star Ratings, marketing, drug coverage, and enrollment — and how to comply.

JC
Jared Clark
· 8 min read
Food Safety & Allergen Compliance Apr 12, 2026

Beverage Equipment Allergen Cross-Contact: Preventive Controls That Keep Products Off FDA Recall Lists

A single equipment failure at Wawa triggered a recall affecting 123+ stores. Learn the allergen preventive controls, CIP validation protocols, and FSMA requirements that prevent beverage recalls.

JC
Jared Clark
· 16 min read
Compliance Apr 12, 2026

Beverage pH and Seal Controls That Prevent FDA Recalls

Learn the quality systems, pH monitoring, and seal integrity controls that prevent FDA beverage recalls. Expert compliance guidance from Certify Consulting.

JC
Jared Clark
· 14 min read
Regulatory News & Compliance Apr 11, 2026

FDA Color Additive Petition: 3 Solvents Facing Regulatory Removal

FDA filed an IACM petition to remove methylene chloride, trichloroethylene & ethylene dichloride from color additive regs. Learn what this means for your compliance.

JC
Jared Clark
· 11 min read
FDA Enforcement & Recalls Apr 10, 2026

Pharmaceutical Adulterant Testing: GMP Controls That Prevent Undeclared Drug Ingredients in Herbal Supplements

The Kian Pee Wan recall found undeclared dexamethasone and cyproheptadine in an herbal supplement. Learn the 21 CFR Part 111 identity testing controls that would have caught it before distribution.

JC
Jared Clark
· 14 min read
Compliance Apr 10, 2026

Undeclared Drug Ingredients in Supplements: How to Prevent FDA Recalls

Learn what quality systems, testing protocols, and manufacturing controls prevent FDA recalls from undeclared drug ingredients in dietary supplements. Expert guidance.

JC
Jared Clark
· 13 min read
Compliance Apr 09, 2026

Cold Chain Controls That Prevent Botulism Recalls in Fresh Garlic

Learn what cold chain failures cause Clostridium botulinum recalls in peeled garlic — and the quality systems, testing protocols, and SOPs that prevent them.

JC
Jared Clark
· 12 min read
Food Safety & Recalls Apr 09, 2026

Cold Chain Controls That Prevent Clostridium Botulinum Recalls in Peeled Garlic and Refrigerated Produce

Tops Issues Recall of Christopher Ranch Peeled Garlic & Garland Fresh Peeled Garlic Because of Possible Health Risk from C. botulinum. Learn the FSMA preventive controls that would have prevented this April 2026 recall.

JC
Jared Clark
· 18 min read
Food Safety & Recalls Apr 08, 2026

Blueroot Health Vital Nutrients Aller-C Recall: Undeclared Egg, Hazelnut & Soy — What Every Supplement Manufacturer Must Know

Blueroot Health issues voluntary allergy alert on Vital Nutrients Aller-C for undeclared egg, hazelnut, and soy. Learn FALCPA compliance, allergen labeling rules, and 21 CFR Part 117 requirements.

JC
Jared Clark
· 16 min read
Compliance Apr 08, 2026

Undeclared Allergens in Supplements: Lessons from the Vital Nutrients Aller-C Recall

Blueroot Health's Vital Nutrients Aller-C recall reveals critical allergen labeling gaps. Learn the compliance lessons and how to prevent undeclared allergen violations.

JC
Jared Clark
· 12 min read
Compliance Apr 07, 2026

Undeclared Allergens: What the Schreiber Foods Recall Teaches Every Food Manufacturer

Learn what Schreiber Foods' almond allergy recall reveals about FDA labeling compliance. Practical steps to prevent undeclared allergen violations. Contact Certify Consulting.

JC
Jared Clark
· 10 min read
Compliance Apr 04, 2026

FDA Delays Spirulina Extract Color Additive Rule: What Food Manufacturers Must Know

FDA has delayed the effective date of its spirulina extract color additive expansion. Learn what changed, which foods are affected, and how to stay compliant.

JC
Jared Clark
· 9 min read
Compliance Apr 03, 2026

FDA Proposes to Reclassify TB Immunity Tests From Class III to Class II

FDA proposes reclassifying TB cell-mediated immunity tests from Class III to Class II. Learn what changed, key deadlines, and how to stay compliant. Guidance inside.

JC
Jared Clark
· 12 min read
Regulatory News Apr 02, 2026

FDA Approves First Gene Therapy for Severe LAD-I

FDA approves Kresladi (marnetegragene autotemcel), the first gene therapy for severe LAD-I. Learn what this approval means for your compliance strategy. Consult Certify Consulting.

JC
Jared Clark
· 10 min read
FDA Enforcement & Recalls Apr 01, 2026

Microbial Contamination Controls That Prevent OTC Drug Product Recalls

A 170-million-unit recall of alcohol prep pads contaminated with a spore-forming bacterium reveals systemic gaps in environmental monitoring, bioburden testing, and CAPA. Here is what manufacturers must fix.

JC
Jared Clark
· 17 min read
FDA Regulatory Compliance Mar 30, 2026

FDA AI Regulation in Drug Manufacturing & QC: What Manufacturers Need to Know

Learn how FDA is regulating AI in drug manufacturing and quality control. Expert analysis of current guidance, GMP expectations, and compliance steps. Get started today.

JC
Jared Clark
· 14 min read
Regulatory Strategy Mar 30, 2026

FDA Artificial Intelligence Framework: 2026 Guide

Understand the FDA's AI/ML framework in 2026. Learn what regulated companies must do now to stay compliant. Expert guidance from Jared Clark, RAC.

JC
Jared Clark
· 15 min read
FDA Regulatory Compliance Mar 30, 2026

FDA Machine Learning Requirements for Drug & Device Submissions

Learn FDA's machine learning requirements for drug and device submissions. Understand SaMD, PCCP, and AI/ML frameworks. Get expert guidance from Certify Consulting.

JC
Jared Clark
· 12 min read
Compliance Mar 25, 2026

FDA Label Claims: Structure-Function vs. Drug Claims

Learn how to distinguish FDA structure-function claims from drug claims, avoid enforcement action, and keep your supplement or food label fully compliant.

JC
Jared Clark
· 12 min read
Compliance Mar 23, 2026

HARPC vs. HACCP: What Changed Under FSMA

Understand the key differences between HARPC and HACCP under FSMA, and what your facility must do to stay compliant. Expert guidance from Certify Consulting.

JC
Jared Clark
· 14 min read
Compliance Mar 22, 2026

FDA Dietary Supplement Adverse Event Reporting: MedWatch Requirements

Learn MedWatch requirements for dietary supplement adverse event reporting. Expert guidance on mandatory vs. voluntary reporting, timelines, and FDA compliance.

JC
Jared Clark
· 12 min read
Compliance Mar 21, 2026

FDA Import Alerts: Detention Without Physical Examination Explained

Learn how FDA Import Alerts and DWPE work, why products get detained, and how to get removed. Expert guidance from Jared Clark at Certify Consulting.

JC
Jared Clark
· 12 min read
Compliance Mar 17, 2026

FDA Warning Letter vs. 483 Observation: Key Differences

Understand the critical differences between an FDA 483 observation and a Warning Letter — and learn which is worse, what each means, and how to respond effectively.

JC
Jared Clark
· 11 min read
Compliance Mar 16, 2026

FDA FSMA Preventive Controls: What Food Facilities Must Have

Learn what FDA FSMA Preventive Controls your food facility must have in place. Expert guidance on compliance requirements, hazard analysis, and audit readiness.

JC
Jared Clark
· 13 min read
FDA Compliance & Enforcement Mar 14, 2026

FDA Consent Decrees: What They Are and How to Avoid Them

Learn what FDA consent decrees are, how they're triggered, real-world costs, and proven strategies to avoid them. Expert guidance from Certify Consulting.

JC
Jared Clark
· 13 min read
Dietary Supplements Mar 12, 2026

Dietary Supplement FDA Compliance: A Complete Guide

Master FDA dietary supplement compliance — cGMP, labeling, NDI notifications, adverse event reporting, and more. Get expert guidance from Certify Consulting.

JC
Jared Clark
· 12 min read
General Mar 10, 2026

How to Choose the Right FDA Consultant: What to Look For

How to Choose the Right FDA Consultant: What to Look For

JC
Jared Clark
· 15 min read
FDA Compliance Mar 10, 2026

How to Respond to FDA Form 483: Timeline, Strategy & Template

Learn exactly how to respond to an FDA Form 483 with a proven timeline, strategy, and response template. Get expert guidance from Certify Consulting.

JC
Jared Clark
· 12 min read
Medical Device Regulatory Affairs Mar 07, 2026

FDA 510(k) vs. De Novo: Choosing the Right Pathway

Learn the key differences between FDA 510(k) and De Novo pathways, when to use each, and how to choose the right route for your medical device. Expert guidance inside.

JC
Jared Clark
· 12 min read
FDA Registration & Compliance Mar 07, 2026

FDA Registration for Foreign Manufacturers: U.S. Agent Requirements

Complete guide to FDA registration for foreign manufacturers—U.S. agent requirements, facility registration steps, and compliance deadlines. Get expert help today.

JC
Jared Clark
· 13 min read
FDA Enforcement & Recalls Mar 07, 2026

Undeclared Drug Ingredients in Supplements: What the Rhino Choco Recall Teaches Every Retailer

Learn how undeclared tadalafil in dietary supplements triggers FDA recalls, criminal liability, and what distributors must do now to stay compliant.

JC
Jared Clark
· 11 min read
FDA Compliance Mar 07, 2026

What to Expect During an FDA Inspection: A Step-by-Step Walkthrough

Learn exactly what happens during an FDA inspection — from opening meeting to Form 483. Expert guidance from Certify Consulting to help you pass the first time.

JC
Jared Clark
· 12 min read
Food Safety & Allergen Compliance Mar 05, 2026

Undeclared Allergens: How to Prevent Wheat & Soy Recalls

Learn what quality systems, allergen controls, and labeling protocols prevent undeclared wheat and soy recalls. Expert FDA compliance guidance from Certify Consulting.

JC
Jared Clark
· 14 min read

Need Help Now? Don't Wait for the Blog.

If you're facing an FDA inspection, responding to a warning letter, or navigating a regulatory submission — schedule a free consultation with Jared Clark, RAC. Expert guidance, no obligation.

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